Granulation tissue formation

Promotes granulation tissue formation in wounds
Granulation tissue is collagen-rich tissue which forms at the site of an injury.
Wound healing, or wound repair, is a complicated process in which the skin by excreting collagen and fibronectin (fibronectin plays a role in wound healing).
Concurrently, re-epithelialization of the epidermis occurs, in which epithelial cells proliferate and ‘crawl’ atop the wound bed, providing cover for the new tissue.
In contraction, the wound is made smaller by the action of myofibroblasts (Myofibroblast is a cell that is in between a fibroblast and a smooth muscle cell ),
which establish a grip on the wound edges and contract themselves using a mechanism similar to that in smooth muscle cells.

When the cells’ roles are close to complete, unneeded cells undergo apoptosis.
In the maturation and remodeling phase, collagen is remodeled and realigned along tension lines and cells that are no longer needed are removed by apoptosis.
However, this process is not only complex but fragile, and susceptible to interruption or failure leading to the formation of chronic non-healing wounds.
Factors which may contribute to this include diabetes, venous or arterial disease, old age, and infection

Local inflammatory reaction stage: bFGF (Basic fibroblast growth factor ) on wound
cells significantly towards activity-induced inflammatory cells, fibroblasts, vascular endothelial cells move to the wound site, activating macrophage phagocytosis,
increased immune activity, significantly reduced the chance of wound infection.

Cell proliferation, differentiation and granulation tissue formation stages:
cell proliferation and repair in the period, one of the most critical steps in the formation of granulation tissue, granulation tissue is the essence of a large number of
capillaries and into the rich fibroblast.

BFGF is fibroblasts, vascular endothelial cells and vascular smooth muscle cell growth and efficient agent, able to strongly
promote the formation of new capillaries, a significant increase in the number of granulation tissue and capillary blood flow, improve microcirculation of the wound,
the organization repair and provide the necessary oxygen-rich nutrients.

Fibroblast collagen synthesis is also the main cells, and granulation tissue collagen is
the major component of interstitial cells, bFGF continuously through the regulation of collagen synthesis, secretion, remodeling and updating, while improving
the structure and strength of repair tissue, the same time, bFGF also stimulates collagenase expression, which can effectively suppress a large number of
collagen synthesis .

And because of excessive precipitation resulting from hypertrophic scar (Hypertrophic scars occur when the body overproduces collagen, which causes the scar to be raised above the surrounding skin ), thereby improving the quality of wound healing, bFGF for damage
tissues of the regeneration of nerve fibers also have a significant role in promoting, improving the organization by accelerating reinnervation and functional
recovery of damaged tissue.

Tissue reconstruction: bFGF by promoting the rapid proliferation of epithelial cells to cover the wound center,
and accelerate wound healing. Although body injury, spontaneously secrete a small amount of bFGF and other growth factors, play a role in self-repair.
But experiments show that spontaneous wound healing is far from maximum speed, its molecular environment in the growth factor did not reach optimal
levels. In particular, a variety of refractory chronic wounds. Some cells was inhibited by the body to lose function of the secretion of growth factors, resulting
in a long and difficult healing wounds.

Burn at different depths or fresh wound, after bFGF treatment, the
treatment group and the negative control group, wound healing time (days) was significantly differences.

Laser treatment of urinary genital ulcer healing rate of 90%, 100% effective. Genital warts is a common sexually transmitted diseases,
and easy to relapse, where by means of laser and other surgical treatment relapse rate of 90% or more, the long-unhealed ulcers after laser treatment,
a higher rate of recurrence. bFGF can promote rapid healing of laser-induced ulcers, genital warts to improve the cure rate and reduce the relapse rate
is important.